I think it should be applauded whenever a game achieves a sense of universal appeal. But instead it seems normally girls that don't play games don't care either way, and girls that DO like games tend to get agitated at the notion that games may need changed to appeal to girls.
I happen to talk regularly with lots of women. Two sisters, a few aunts, my mom, wife, daughter, and sister-in-laws to boot. None of them have been willing to sit down and try my creature creator. However, my 2 male friends that I talk to at work have all tried it. Unfortunately I don't have a father, brothers, or anything like that, but I really hope that Spore ultimately finds a market with a women that ordinarily would never play games.
I know I'm still trying to get members of my family to try it.